Scale Up Synthesis

Strong team with excellent capabilities and expertise to deliver small or focused and large libraries

Large collections of standard commercial building blocks (amines, acids, isocyanates, sulfonyl chlorides etc.)

Small, focused libraries (20 - 500 compounds) to allow for rapid SAR exploration

Large libraries (1,000 - 10,000 compounds)

High-throughput or Parallel Medicinal Chemistry, often cherry-picked, and more complex chemistry

Track record of delivering ^~88,000 compounds in the library space (small or focused and large libraries)

Capacity to deliver 6,000 compounds per month

Multiple standard orbital shakers; Multiple shakers with heating/cooling capacity

Parallel inert atmosphere equipment

CEM Discovery Microwave with robot

Large shaking table for large libraries

Parallel synthesizers for small libraries (15+)

Purification

Provides both analysis and purification support

Method development

Open-access systems with trained chemists

Purification including chiral separation Maintenance of instruments

7 x LC-MS (Agilent 1260/6120)

1 x GC MS

22 x HPLC (Agilent and Shimadzu)

1 x GC

8 x Prep-HPLC (Gilson 281)

8 x Prep-MPLC (Biotage/Agela)

1 x NMR (Bruker-400MHz AVANCEIII): 1D, 2D, 1H, 13C, 19F, 11B, 29Si, 31P

3 x Lyophilizer

Small/focused libraries

Large libraries

Packaging/Shipment