Kinetic and thermodynamic solubility
LogD
pKa
Chemical stability
Hepatocyte stability
Liver microsomal stability
Recombinant CYP450 stability
Liver S9 fraction stability
Intestine microsomal stability
Plasma stability
Blood stability
PAMPA
Caco-2 cells
MDR1-MDCK cells
Plasma protein binding
Microsomal protein binding
Tissue protein binding
Blood to plasma ratio (Cb/Cp)
Red blood cell to plasma partition (CRBC/Cp)
P-gp/Caco-2 cells
BCRP/Caco-2 cells
MDR1-MDCK cells
OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2K/HEK293 cells
CYP450 inhibition (inhibition% or IC50)
CYP450 time dependent inhibition (inhibition% or IC50 shift)
CYP450 induction using cryo-preserved hepatocytes (human, rat, mouse)
Metabolite identification in liver microsomes and other in vitro metabolic reaction systems
Metabolite identification in plasma and other fluids or tissues from PK or TK studies
Reactive metabolite GSH trapping
Metabolite production, isolation, purification and structure determination via in vitro or in vivo metabolic reaction systems
CYP450 reaction phenotyping (rhCYP and chemical inhibition)
UGT reaction phenotyping (rhUGT and chemical inhibition)
5 working days except cell-based assays (10 working days), metabolite identification and uptake transporter (10 working days), whole blood assay (10-15 working days), and CYP450 induction (15 working days)
Home
