FRAGMENT-BASED DRUG
DISCOVERY (FBDD)

A general-purpose, highly diverse fragment library (2000 - 3000 members), cost effective, easy to upgrade/improve

Inclusion of novel scaffolds (e.g. natural product/TCM inspired), relaxed Ro3

Inclusion of most important pharmacophores to effectively cover drug-like space

Exclusion of functional groups with known structural alerts (reactive, toxic, aggregators, PAINS)

Cherry-picking from commercially available libraries to cover essential pharmacophores but also with high diversity

Fragments selected with accessible synthetic vectors, and/or easy analoging by commercial cataloging

Fragments with novel scaffolds will differentiate BioDuro-Sundia Fragment Library from the competitions, increase its value (delivering novel hits) and attractiveness

Surface Plasmon Resonance (SPR)

Robust with wide dynamic range (Kd: nM – mM)

Quantitative binding info: kon, koff, Kd

Binding stoichiometry

Very low protein consumption

High-throughput (Biacore 8K)

Fragment Library Screening by SPR

BioDuro-Sundia provides Fragment Library Screening and follow-up studies with affinity and kinetics characterization by SPR