We employ distinct and customized ‘Fit-for-Purpose’ drug discovery strategies to increase success rates. Smarter design focused on fewer compounds reduces time and cost when compared to the common approach of broad synthesis of many compounds “because they can be made”.
Our ‘Fit-for-Purpose’ IDD Platform informs timely and frequent ‘Go / No-Go’ decisions based on a defined screening cascade towards a clear target product profile (TPP).
We can engage clients at any stage, starting with early hit identification and hit services, or starting with late lead de-risking and forward-thinking backup strategies.
Typical Timeline of BioDuro-Sundia IDD Program:
Hit ID - Quality and diversity of initial hits determines chance of success; careful triage is essential.
LO - Ideally progress multiple, structurally distinct and patentable lead series and progress into late LO as early as possible – don’t wait for the “perfect” molecule, but move several differentiated compounds forward if possible.
H2L - Focus on creating novelty and FTO through scaffold-hopping, nitrogen-walk, unique building blocks, while monitoring drug-likeness parameters and ADME early; taking advantage of handles for quick parallel SAR exploration.
Late LO/PCC - Narrow down to 2-3 compounds to select for PCC candidate and backup compound(s); connect with PRD and FormDev (“Solution Engine”) scientists early.