Peptide Chemistry

Drug Substance Process Development

BioDuro develops peptide synthesis processes using SPPS, LPPS, and hybrid approaches, with strategies tailored to the structural and process requirements of each molecule.

Our process development capabilities support a broad range of peptide modalities, including linear, cyclic and macrocyclic, modified, and conjugated peptides, as well as complex chemistries involving unnatural amino acids and other structural modifications.

Scale-Up & Drug Substance Manufacturing

At kilolab scale, BioDuro translates laboratory processes into manufacturing-ready workflows, integrating synthesis and purification to address scale-dependent challenges early and facilitate efficient technology transfer into GMP production.

Commercial GMP manufacturing extends this process knowledge into large-scale production, preparative purification, and downstream operations, helping preserve process robustness and product quality while enabling reliable supply as programs advance.

Solid-Phase and Liquid-Phase Peptide Synthesis

BioDuro offers both solid-phase peptide synthesis and liquid-phase peptide synthesis, allowing the development approach to be selected around peptide complexity, quantity, and scale-up requirements.

Solid-phase peptide synthesis capabilities extend to 800 mmol and support linear peptides, cyclic peptides, and peptide drug conjugates. Liquid-phase peptide synthesis is also available for projects where it provides a practical route to larger-scale production.

Purity and Product Options

Peptide purity requirements vary depending on whether the material will be used for initial research, biological testing, analytical standards, or later-stage development.

BioDuro offers peptide products at purity targets such as greater than 90%, 95%, and 98%, depending on sequence, complexity, scale, and intended application. Available product options include multiple salt forms and a broad range of modifications and conjugates.

Final specifications and timelines are established after reviewing the peptide sequence, required quantity, target purity, modifications, and analytical requirements.

Connected Peptide Development Services

Peptide programs can also draw on BioDuro’s Biology, DMPK, and Formulation capabilities. This allows synthesized peptides to move into biochemical and cellular testing, in vivo evaluation, developability assessment, and oral peptide formulation work when required.

BioDuro’s formulation team also supports oral peptide delivery approaches, including enteric coating and permeability-enhancement strategies.